Henry Manasseth (Henry Mossuck) was the son of Luke Mossuck, a member of the Tunxis community at Farmington, Connecticut. As a child, he may have been known as Harry Prin. In 1808, Henry inherited his father's property in Farmington, but, being a minor, Seth Wadsworth acted as his guardian and sold a piece of the land to defray administrative services.
Luke Mossuck was the son of Solomon Mossuck and Eunice Wawowos of the Tunxis community in Farmington, Connecticut. He had at least three sons, Daniel, Newton, and Henry. As a young man, he was a student under Joseph Johnson's tutelage. In that capacity, he was rebuked by his teacher in the winter of 1772 for misbehaving. Luke removed to Oneida Country sometime before 1795, where he received lot 61. This tract of land was forfeited in 1797, as he had gone back to Connecticut.